Enceph UK

A 5 year Programme Grant on Understanding and Improving the Outcome of Encephalitis, NIHR funded (lead Professor Tom Solomon).

For further information please visit: www.encephuk.org

enceph image
Patients Recruited
341

Key Contacts

Role Name Email Telephone
Clinical Research Fellow Dr Sylviane Defres sdefres@liv.ac.uk 0151 795 9600
Programme Manager Hayley Jelleyman h.e.jelleyman@liverpool.ac.uk 0151 795 9672
Data Manager Kieran Crabtree Kieran.Crabtree@liverpool.ac.uk 0151 795 9670


Publications
> The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome.
> Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.
> The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults.
> Zika virus and neurological disease--approaches to the unknown.
> Innate and adaptive immune responses to tick-borne flavivirus infection in sheep.
> Diagnostic Pathways as Social and Participatory Practices: The Case of Herpes Simplex Encephalitis.
> Corrigendum to "The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent Adults" [J Infect 72 (2016) 405-438].
> Guillain-Barré syndrome associated with Zika virus infection.
> CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF.
> Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G?T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis.
> Neuroimaging in encephalitis: analysis of imaging findings and interobserver agreement.
> Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia.
> Subdural Empyema Caused by Neisseria meningitidis: A Case Report and Review of the Literature.
> Arterial ischemic stroke in HIV: Defining and classifying etiology for research studies.
> Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study.
> When should we test for voltage-gated potassium channel complex antibodies? A retrospective case control study.
> The impact of 2015 neuromyelitis optica spectrum disorders criteria on diagnostic rates.
> Fatal encephalitis associated with Zika virus infection in an adult.
> Immunoglobulin in the Treatment of Encephalitis (IgNiTE): protocol for a multicentre randomised controlled trial.
> A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.
> Zika virus and Guillain-Barré syndrome.
> A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology.
> Acute bacterial meningitis in adults - Authors' reply.
> What proportion of AQP4-IgG-negative NMO spectrum disorder patients are MOG-IgG positive? A cross sectional study of 132 patients.
> Care beyond the hospital ward: understanding the socio-medical trajectory of herpes simplex virus encephalitis.
> The Role of Human Immunodeficiency Virus-Associated Vasculopathy in the Etiology of Stroke.
> Measles induced encephalitis
> Management of acute confusion in patients with CNS infections
> Seizures and encephalitis: clinical features, management, and potential pathophysiologic mechanisms
> Lumbar puncture: diagnosing acute central nervous system infections.
> Management of suspected viral encephalitis in adults - Association of British Neurologists and British Infection Association National Guideline